Territory

Cécile Legallais

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Research Institution – University

LABORATORY OF BIOMECHANICS AND BIOENGINEERING UMR CNRS 7338 – UTC

Director

Researcher's interest in a few words:

Main field of activity

technology development;
biologic model development.

Target organs

liver;
kidney;
pancreas.

Main collaborations

Prof. Y. Sakai & Dr. F. Soncin – LIMMS, UMI CNRS 2820 & University of Tokyo;
Prof. S. Bencherif – Northeastern University, Boston;
Dr A. Treizebré – IEMN, Lille;
Dr A. Dubart-Kupperschmitt – INSERM U1193, Villejuif;
Prof. J-C. Duclos-Vallée – Centre Hépato-Biliaire, Hopital Paul Brousse, Villejuif & FHU Hépatinov;
Fluigent;
HCS Pharma.

Keywords

Type/models systems

Spheroids & organ-on-a-chip;

Physio-pathological models

Metabolic disorders;

Application areas

Organ development and physiopathology studies, diseases models, organ interaction studies, toxicity, drug safety & toxicology testing.

Technologies

microfluidic chips & biosensors;
perfusion systems and control strategies, real-time monitoring, flow controller, pressure controller & temperature controller;
tissue engineering.

Main research or activities topics

Design, development and assessment of microfluidic devices allowing perfused and 3D cell culture. Application to liver, liver-kidney and liver-pancreas interactions. Inclusion of alginate cryogels in the microsystems to enhance the formation of 3D structures, mechanical and biological characterization. Bioinspired approached to mimic a liver sinusoid. Parallelization & monitoring of the perfusion to allow medium throughput.

Contact

Adresse

UTC – Centre de recherche de Royallieu
60200 Compiègne
France